بحر قسم الصيدلة ( معلومات طبية صيدلانية متنوعة )💊

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‏﷽
۝ إِنَّ اللَّهَ وَمَلائِكَتَهُ يُصَلُّونَ عَلَى
النَّبِيِّ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا
عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا ۝ ﷺ

(25) September (2024) 💉💊

اليوم العالمي للصيادلة، المهنة التي تجمع بين الإنسانية والرحمة... بين الصدق والنزاهة... بين الجرأة والخبرة... بين القدرة في التعامل والصبر والتحمل.. ‎💙
كل عام وجميع الصيادلة بخير
كل عام والصيدلي هو الجندي المجهول في منظومة الدواء
كل عام وهو الخبير الاول بالدواء ....

فلا دواء بدون صيدلي 💊

نحن الترياق لكل داء ..!
نحن كبسولات الأمل، ومراهم الشفاء، واقراص السعادة لكل ألم ..!
كل عام ونحن بلسم لجراح هذا الوطن ....
كل عام والخير فينا، وكل عام ونحن الدواء لجراح المرضى واوجاعهم...💊💛

Happy Pharmacists Day...

افضل ٣ بوتات في تأريخ تلجرام لربح العملات 100%



وسحبهن سيكون قريب






وسأرتبها لكم حسب قوة البوت وقوة السحب واخذها الأقل للوقت

أول اثنين بوتات ما تاخذ من وقتك كل يوم حتى ٣ دقائق اما الثالث كله على نشاااطك


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طبعاً في بوتات ككككككثير الا انا اخترت لكم الافضل والاضخم والأوثق


طبعا البوتات مضمونة انها اتربحكم ١٠٠% والربح كله على نشاط الشخص وسهلات ما تحتاج شي



والذي يشتي يبحث عنهن بيتيوب او يتواصل معي واشرح له اذا يشتي


بالتوفيق

12_ Nalbuphine

Dose:
🔣 Analgesia: 0.1-0.2mg/Kg
🔣 Anaesthesia induction: 0.3-3mg/Kg over 10-15min
🔣 Anaesthesia maintenance: 0.25-0.5mg/Kg

Preparation:
🔣 10mg/ml
🔣 20mg/ml

Note:
🔣 Nalbuphine has an analgesic potency equivalent to that of morphine.
🔣 Causes less nausea and vomiting, psychotomimetic effects, and dependence than does morphine.
🔣 Reversed by naloxone.

anaesthesia analgesia opioid





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هل صليت على النبي ﷺ‏ اليوم
‏تصلي عليه مرة
‏ويصلي عليك الله 10 مرات
اللَّهُمَّ صَلِّ وَسَلِّم عَلَى نَبِيِّنَا مُحَمَّد وعلى آله وصحبه أجمعين

1⃣1⃣ _Remifentanil

Uses:
🔣 Analgesia, Sedation, Anaesthesia.

Dose:
🔣 Anaesthesia: 0.5-2μg/Kg/min IV infusion (or) 1-4μg/Kg IV bolus
🔣 Analgesia: 0.05-0.2μg/Kg IV infusion.

Presentation:
🔣 White lyophilized powder, containing remifentanil hydrochloride in a glycine buffer in 1mg, 2mg, 5mg vial

Note:
🔣 Context sensitive half life of Remifentanil is 3-5min and the drug effect wears off rapidly in 5-10min.
🔣 Chest wall rigidity (the ‘wooden chest’ phenomenon) may occur after the administration.




opioid_analgesia



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🔟_Pentazocine💊

Dose:
➡️ 0.5mg/Kg IV or IM

Presentation:
➡️ 30mg/cc ampoule

Note:
➡️ κ opioid receptor agonist & μ opioid receptor antagonist.


analgesia_opioid






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9⃣_Pethidine

Dose:
= 0.5-2mg/Kg Intravenous or intramuscular.

Presentation:
= 50mg/cc ampoule

Note:
= May cause hypotension due to histamine release and alpha adrenergic blockade.
= May also cause tachycardia.
= It is also used for post op shivering.


opioid_analgesia



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8⃣_Buprenorphine💊

Dose:
= 2-6mcg/Kg IV every 6-8hrs

Preparation:
= 0.3mg/ml ampoule

Note:
= may cause histamine and tryptase release from lung parenchymal mast cells and may increase the PVR.
= 25 times as potent an analgesic as morphine.


opioid_analgesia



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7⃣_ Tramadol 💊

Dose:
= 1-2mg/Kg IV

Preparation:
= 50mg/ml ampoule

Note:
= Reduced doses are recommended in patients with hepatic and renal dysfunction.
= It is also used for postoperative shivering.


opioid/ analgesia


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فهرس ادوية المسكنات (Analgesia ) / لقناة بحر الصيدلة وإن شاء الله كل يوم دواء

1_ Paracetamol

2_ Diclofenac

3_Ketorolac

4_ Ketamine

5_ Morphine

6_ Fentanyl

7_ Tramadol

8_ Buprenorphine

9_ Pethidine

10_ Pentazocine

6⃣_ Fentanyl

Dose:
= 0.5-3mcg/Kg IV
= 0.5-2mcg/Kg/hr IV infusion
= High doses of upto 50mcg/Kg can also be used in general anaesthesia for prolonged surgeries

Preparation:
= 50mcg/cc ampoule

Note:
= can cause Wooden chest phenomenon characterized by chest wall rigidity.
= causes respiratory depression, bradycardia.
= produces miosis

opioid analgesia


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5⃣.MORPHINE

Uses:
🔣 Management of severe acute and chronic pain
Postoperative pain control
🔣 Palliative care for pain and dyspnea in terminal illnesses
🔣 Preoperative medication and anesthesia adjunct

Dose:
🔣 Intravenous: 0.05-0.1 mg/kg every 2-4 hours as needed
🔣 Oral: 0.2-0.5 mg/kg every 4-6 hours as needed
🔣 Epidural: 0.03-0.1 mg/kg as a single dose
🔣 Intrathecal: 5-10mcg/kg as a single dose

Presentation:
🔣 Injection: 1 mg/mL, 2 mg/mL, 5 mg/mL, 10 mg/mL
🔣 Oral tablets: 10 mg, 20 mg, 30 mg, 60 mg
🔣 Oral solution: 10 mg/5 mL

Note:
🔣 Mechanism of action: Morphine is a potent opioid agonist that primarily acts on the mu-opioid receptors in the central nervous system, producing analgesia, euphoria, and sedation.
🔣 Onset and duration: IV administration typically has an onset of 5-10 minutes with a duration of 3-5 hours. Oral administration has an onset of 30-60 minutes with a duration of 4-6 hours.
🔣 Side effects: Common side effects include respiratory depression, constipation, nausea, vomiting, drowsiness, and urinary retention. Long-term use can lead to tolerance, dependence, and addiction.
🔣 Contraindications: Contraindicated in patients with severe respiratory depression, acute or severe bronchial asthma, and known hypersensitivity to morphine.
🔣 Drug interactions: Use with caution with other central nervous system depressants, such as benzodiazepines, alcohol, and other opioids, as this can enhance sedative and respiratory depressant effects. Avoid use with MAO inhibitors within 14 days due to the risk of severe and unpredictable reactions.
🔣 Morphine overdose is treated with Naloxone 0.01mg/Kg; dose repeated 2-3min if necessary.


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4⃣. Ketamine

Dose:
= 4-10mg/Kg IM (induction)
= 0.5-2mg/Kg IV (induction)
= 10-50mcg/Kg/min (anaesthesia)
= 0.2-0.75mg/Kg IV (sedation & analgesia)
= 5-20mcg/Kg/min (sedation & analgesia)

Preparation:
= 50mg/cc ampoule

Notes:
= preferred drug for anaesthesia in patients with shock
= Increases sympathetic tone and thereby increases HR, BP, CO.
= Preserves airway reflexes.


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3⃣ Ketorolac

Uses:


Dose:
🔣 0.5mg/Kg/dose IM or IV 6th hourly

Presentation:
🔣 30mg/cc, 15mg/cc

Note:
🔴 Prolonged use can cause analgesic nephropathy.



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2⃣. Diclofenac

Dose:
➡️ 1-1.5mg/Kg IV
➡️ 1-2mg/Kg IM

Presentation:
➡️ 75mg/ml ampoule
➡️ 75mg/3ml ampoule

Note:
➡️ Non specific Cyclooxygenase enzyme (COX) inhibitor.
➡️ Nephrotoxic.




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1⃣. Paracetamol

Dose:
= 10-15mg/Kg IV

Preparation:
= 1g in 100ml

Note:
= Use with caution in patients with renal & hepatic dysfunction.



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Analgesia Index