Hematology Updates @haematology_updates Channel on Telegram

Hematology Updates

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All the atest articles, research and news from worlds leading Haematology Journals.

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Hematology Updates (English)

Are you passionate about staying up-to-date with the latest advancements in the field of Hematology? Look no further than 'Hematology Updates'! This Telegram channel, with the username @haematology_updates, is your go-to source for all the newest articles, research, and news from the world's leading Haematology Journals.

Whether you are a medical professional, student, or simply someone with a keen interest in this specialized field, this channel provides a platform for learning and discussion. Join a community of like-minded individuals who are dedicated to expanding their knowledge and staying informed about the latest developments in Hematology.

In addition to sharing valuable resources, 'Hematology Updates' also offers a discussion group where members can engage with one another, ask questions, and exchange ideas. It's the perfect place to connect with peers and experts in the field, fostering a collaborative and supportive environment for all participants.

Don't miss out on the opportunity to be part of this dynamic community that is passionate about Hematology. Join 'Hematology Updates' today and stay ahead of the curve when it comes to the latest research and news in this fascinating field of study!

Hematology Updates

08 Nov, 17:09


Hemophagocytic lymphohistiocytosis: current treatment advances, emerging targeted therapy and underlying mechanisms

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01621-x

Hematology Updates

08 Nov, 15:39


Rapid growth of acquired <i>UBA1</i> mutations predisposes male patients to low-risk MDS

https://www.nature.com/articles/s41375-024-02397-2

Hematology Updates

07 Nov, 10:31


Hemophilia B: Gene Therapy Shows Promise
https://www.medscape.com/viewarticle/hemophilia-b-gene-therapy-shows-promise-2024a1000jys?src=rss

Fidanacogene elaparvovec gene therapy may usher in a new era in the treatment of hemophilia B.
Medscape Medical News

Hematology Updates

06 Nov, 18:53


Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01625-7

Hematology Updates

06 Nov, 01:19


Genome-first determination of the prevalence and penetrance of eight germline myeloid malignancy predisposition genes: a study of two population-based cohorts

https://www.nature.com/articles/s41375-024-02436-y

Hematology Updates

05 Nov, 18:32


Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01622-w

Hematology Updates

05 Nov, 07:58


Pre-emptive therapeutic decisions based on measurable residual disease status in acute myeloid leukemia: ready for prime time?

https://www.nature.com/articles/s41375-024-02458-6

Hematology Updates

04 Nov, 11:27


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Hematology Updates

02 Nov, 23:38


Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia

https://www.nature.com/articles/s41375-024-02455-9

Hematology Updates

31 Oct, 21:16


Post-transplant cyclophosphamide separates graft-versus host disease and graft versus leukemia effects after HLA-matched stem-cell transplantation for acute myeloid leukemia

https://www.nature.com/articles/s41375-024-02445-x

Hematology Updates

31 Oct, 21:15


The dynamic evolution of lineage switch under CD19 CAR-T treatment in non-KMT2A rearranged B-ALL patients

https://www.nature.com/articles/s41375-024-02449-7

Hematology Updates

30 Oct, 14:34


Development and validation of the post-CAR prognostic index for large B-cell lymphoma patients after CAR-T progression in third or later line treatment

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01608-8

Hematology Updates

30 Oct, 14:33


Long-term survival with donor CD19 CAR-T cell treatment for relapsed patients after allogeneic hematopietic stem cell transplantation

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01626-6

Hematology Updates

30 Oct, 02:22


[Articles] Maternal and obstetric outcomes in women with pregnancy-associated haematological malignancies: an observational nationwide cohort study

https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(24)00288-6/fulltext?rss=yes

Hematology Updates

30 Oct, 02:21


[Comment] The Global Fund should extend its mandate to include universal access to hydroxyurea

https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(24)00275-8/fulltext?rss=yes

Hematology Updates

30 Oct, 02:20


[In Focus] Oh no, the light chain ratio

https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(24)00310-7/fulltext?rss=yes

Hematology Updates

29 Oct, 16:46


Tucidinostat plus pediatric-inspired chemotherapy for newly diagnosed adult ETP-ALL/LBL: a single-arm, phase 2 trial

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01624-8

Hematology Updates

29 Oct, 16:09


Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines

https://www.nature.com/articles/s41375-024-02400-w

Hematology Updates

28 Oct, 20:23


Validation and refinement of the 2022 European LeukaemiaNet genetic risk classification of acute myeloid leukaemia patients receiving allogeneic haematopoietic cell transplantation

https://www.nature.com/articles/s41375-024-02440-2

Hematology Updates

27 Oct, 10:56


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Hematology Updates

25 Oct, 21:32


Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapy

https://www.nature.com/articles/s41375-024-02444-y

Hematology Updates

25 Oct, 21:31


Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma

https://www.nature.com/articles/s41375-024-02446-w

Hematology Updates

23 Oct, 12:06


NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation

https://www.nature.com/articles/s41375-024-02438-w

Hematology Updates

22 Oct, 18:50


Robust anti-myeloma effect of TAS0612, an RSK/AKT/S6K inhibitor, with venetoclax regardless of cytogenetic abnormalities

https://www.nature.com/articles/s41375-024-02439-9

Hematology Updates

22 Oct, 18:49


The <i>BIM</i> deletion polymorphism potentiates the survival of leukemia stem and progenitor cells and impairs response to targeted therapies

https://www.nature.com/articles/s41375-024-02418-0

Hematology Updates

22 Oct, 18:48


Retraction Note: SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide

https://www.nature.com/articles/s41375-024-02443-z

Hematology Updates

22 Oct, 14:10


Global cancer statistics for adolescents and young adults: population based study

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01623-9

Hematology Updates

21 Oct, 17:10


Correction: Phase IB part of LOC-R01, a LOC network non-comparative randomized phase IB/II study testing R-MPV in combination with escalating doses of lenalidomide or ibrutinib for newly diagnosed primary central nervous system lymphoma (PCNSL) patients

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01620-y

Hematology Updates

21 Oct, 12:40


Genome-wide CRISPR screen identifies MAD2L1BP and ANAPC15 as targets for brentuximab vedotin sensitivity in CD30+ peripheral T-cell lymphoma

https://www.nature.com/articles/s41375-024-02441-1

Hematology Updates

18 Oct, 17:11


Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance

https://www.nature.com/articles/s41375-024-02431-3

Hematology Updates

18 Oct, 03:51


CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL

https://www.nature.com/articles/s41375-024-02421-5

Hematology Updates

16 Oct, 11:53


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Hematology Updates

16 Oct, 10:21


Myeloma: Isa-KRd Induction Shows High MRD Responses
https://www.medscape.com/viewarticle/myeloma-isa-krd-induction-shows-high-mrd-responses-2024a1000ifr?src=rss

Interim analysis of first MIDAS trial findings showed "highest rate of response and MRD negativity to date."
Medscape Medical News

Hematology Updates

16 Oct, 01:05


Anagrelide and idarubicin combination induces GSDME-mediated pyroptosis as a potential therapy for high-PDE3A acute myeloid leukemia

https://www.nature.com/articles/s41375-024-02437-x

Hematology Updates

15 Oct, 00:24


Mapping the cell therapy landscape: insights into clinical trials and regulatory advances in China

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01616-8

Hematology Updates

15 Oct, 00:23


NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01618-6

Hematology Updates

14 Oct, 11:42


Functional variant rs9344 at 11q13.3 regulates <i>CCND1</i> expression in multiple myeloma with t(11;14)

https://www.nature.com/articles/s41375-024-02363-y

Hematology Updates

14 Oct, 10:50


πŸ”΄ Original Article

🚨 Hematologic Cancer After Gene Therapy for Cerebral Adrenoleukodystrophy (CALD)

🧬 Study Focus:
Gene therapy with elivaldogene autotemcel (eli-cel) shows promise for treating CALD but raises concerns about oncogenesis.

πŸ”¬ Key Results:

β€’ Hematologic cancer developed in 7 out of 67 patients after eli-cel therapy.
β€’ Types of cancer: Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
β€’ Gene insertions linked to oncogenes like MECOM–EVI1 and PRDM16.

⚠️ Outcome:

β€’ 5 patients underwent allogeneic stem-cell transplantation; 4 are MDS-free.
β€’ 1 AML patient is in remission post-transplantation.

πŸ‘¨β€βš•οΈ Conclusion:
Gene therapy offers potential but carries risks of clonal evolution and oncogenesis.

πŸ“„ Full study available in NEJM:
N Engl J Med 2024;391:1287-1301. DOI: 10.1056/NEJMoa2405541
https://www.nejm.org/doi/full/10.1056/NEJMoa2405541

@The_NEJM

Hematology Updates

13 Oct, 22:46


Increased Epsteinβ€’Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01612-y

Hematology Updates

13 Oct, 22:45


Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01615-9

Hematology Updates

12 Oct, 20:55


Correction: A single-cell and spatially resolved atlas of human osteosarcomas

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01619-5

Hematology Updates

12 Oct, 11:38


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Hematology Updates

12 Oct, 08:55


🌟FDA Approves First Non-Factor and Once-Weekly Treatment for Hemophilia A or B


The FDA has just approved Hympavzi (marstacimab-hncq) – the FIRST once-weekly, non-factor treatment for Hemophilia B patients! πŸ™Œ

This game-changing therapy is designed for adults and children (12+) with Hemophilia A (without factor VIII inhibitors) or Hemophilia B (without factor IX inhibitors). It helps prevent or reduce the frequency of bleeding episodes, making life easier for those managing the condition.

#medicalnews

Read more

@Updates_in_Medicine

Hematology Updates

11 Oct, 20:50


Consensus, debate, and prospective on pancreatic cancer treatments

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01613-x

Hematology Updates

09 Oct, 19:22


Redefining chimeric antigen receptor T-cell (CAR-T) regulation: China’s responses to address secondary cancer risks of CAR-T therapy

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01602-0

Hematology Updates

09 Oct, 19:21


The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01610-0

Hematology Updates

09 Oct, 18:52


Offering patients a second chance: what is the minimum cure rate needed to justify allogeneic hematopoietic cell transplantation?

https://www.nature.com/articles/s41375-024-02384-7

Hematology Updates

09 Oct, 11:31


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