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Nature Medicine

25 Oct, 09:39

Political polarization and health
https://www.nature.com/articles/s41591-024-03307-w

Nature Medicine, Published online: 25 October 2024; doi:10.1038/s41591-024-03307-w (https://www.nature.com/articles/s41591-024-03307-w)Political polarization is an understudied determinant of health. This Review describes the types of political polarization and how they impact the health of populations and individuals, including potential mitigation strategies and research priorities.

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Nature Medicine

25 Oct, 09:38

How health technology can ease the terrible toll of war
https://www.nature.com/articles/s41591-024-03335-6

Nature Medicine, Published online: 25 October 2024; doi:10.1038/s41591-024-03335-6 (https://www.nature.com/articles/s41591-024-03335-6)Trauma and infections increase during war, while routine cancer care is disrupted, but telemedicine, AI chatbots and electronic health records can help.

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Nature Medicine

24 Oct, 11:00

Subclassification of obesity for precision prediction of cardiometabolic diseases
https://www.nature.com/articles/s41591-024-03299-7

Nature Medicine, Published online: 24 October 2024; doi:10.1038/s41591-024-03299-7 (https://www.nature.com/articles/s41591-024-03299-7)A precision medicine approach used unsupervised clustering to identify five distinct phenotypic profiles that can better predict risks of cardiometabolic disease compared with those ascertained based on the additive value of body mass index and other biomarkers, and validated these findings across four independent cohorts.

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Nature Medicine

24 Oct, 10:59

An explainable foundation model for drug repurposing
https://www.nature.com/articles/s41591-024-03333-8

Nature Medicine, Published online: 24 October 2024; doi:10.1038/s41591-024-03333-8 (https://www.nature.com/articles/s41591-024-03333-8)A foundation model leverages large-scale medical knowledge to repurpose drugs for diseases that currently lack approved treatments, and provides explanations to support clinicians’ decisions.

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Nature Medicine

23 Oct, 13:11

Global genomic surveillance of monkeypox virus
https://www.nature.com/articles/s41591-024-03370-3

Nature Medicine, Published online: 23 October 2024; doi:10.1038/s41591-024-03370-3 (https://www.nature.com/articles/s41591-024-03370-3)An analysis of all available Mpox virus sequences, including 10,670 sequences from 65 countries collected between 1958 and 2024 unveils the circulation pattern and spatiotemporal dynamics underlying the spread of the different viral clades.

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Nature Medicine

23 Oct, 13:10

Author Correction: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9
https://www.nature.com/articles/s41591-024-03350-7

Nature Medicine, Published online: 23 October 2024; doi:10.1038/s41591-024-03350-7 (https://www.nature.com/articles/s41591-024-03350-7)Author Correction: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

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Nature Medicine

22 Oct, 12:28

Economics, equity and avoidable mortality
https://www.nature.com/articles/s41591-024-03303-0

Nature Medicine, Published online: 22 October 2024; doi:10.1038/s41591-024-03303-0 (https://www.nature.com/articles/s41591-024-03303-0)Two new studies characterize the unequal global burden of avoidable mortality and the economic value of reducing it — providing evidence to support targeted investment in health and longevity.

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Nature Medicine

22 Oct, 12:27

The Cannabis and Health Research Initiative will help integrate medicinal cannabis in healthcare
https://www.nature.com/articles/s41591-024-03288-w

Nature Medicine, Published online: 22 October 2024; doi:10.1038/s41591-024-03288-w (https://www.nature.com/articles/s41591-024-03288-w)The Cannabis and Health Research Initiative will help integrate medicinal cannabis in healthcare

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Nature Medicine

22 Oct, 12:26

Safety principles for medical summarization using generative AI
https://www.nature.com/articles/s41591-024-03313-y

Nature Medicine, Published online: 22 October 2024; doi:10.1038/s41591-024-03313-y (https://www.nature.com/articles/s41591-024-03313-y)Google’s development of MedLM found that risk management processes were an essential tool to protect patient safety.

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Nature Medicine

21 Oct, 16:49

Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial
https://www.nature.com/articles/s41591-024-03305-y

Nature Medicine, Published online: 21 October 2024; doi:10.1038/s41591-024-03305-y (https://www.nature.com/articles/s41591-024-03305-y)A randomized, sham-controlled, superiority trial of a 10-week course of home-based transcranial direct current stimulation found greater improvements in depressive symptoms with active compared to sham stimulation in major depressive disorder.

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Nature Medicine

18 Oct, 16:28

An ethics assessment tool for artificial intelligence implementation in healthcare: CARE-AI
https://www.nature.com/articles/s41591-024-03310-1

Nature Medicine, Published online: 18 October 2024; doi:10.1038/s41591-024-03310-1 (https://www.nature.com/articles/s41591-024-03310-1)An ethics assessment tool for artificial intelligence implementation in healthcare: CARE-AI

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Nature Medicine

17 Oct, 14:25

How to prepare for the next inevitable Ebola outbreak: lessons from West Africa
https://www.nature.com/articles/s41591-024-03295-x

Nature Medicine, Published online: 17 October 2024; doi:10.1038/s41591-024-03295-x (https://www.nature.com/articles/s41591-024-03295-x)Many lessons have been learned 10 years after the Ebola virus disease outbreak in West Africa, but urgent work is now needed to prevent another outbreak.

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Nature Medicine

17 Oct, 14:24

Systems education can train the next generation of scientists and clinicians
https://www.nature.com/articles/s41591-024-03315-w

Nature Medicine, Published online: 17 October 2024; doi:10.1038/s41591-024-03315-w (https://www.nature.com/articles/s41591-024-03315-w)Systems education can train the next generation of scientists and clinicians

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Nature Medicine

16 Oct, 11:57

Health AI needs meaningful human involvement: lessons from war
https://www.nature.com/articles/s41591-024-03311-0

Nature Medicine, Published online: 16 October 2024; doi:10.1038/s41591-024-03311-0 (https://www.nature.com/articles/s41591-024-03311-0)Health AI needs meaningful human involvement: lessons from war

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Nature Medicine

16 Oct, 11:53

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Nature Medicine

15 Oct, 14:14

Cell therapy for neurological disorders
https://www.nature.com/articles/s41591-024-03281-3

Nature Medicine, Published online: 15 October 2024; doi:10.1038/s41591-024-03281-3 (https://www.nature.com/articles/s41591-024-03281-3)This Review summarizes the state of clinical research on cell replacement therapy for neurological conditions, and discusses the challenges facing the field, from immunosuppression and therapeutic delivery to cost issues.

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Nature Medicine

14 Oct, 16:33

How to make cardiology clinical trials more inclusive
https://www.nature.com/articles/s41591-024-03273-3

Nature Medicine, Published online: 14 October 2024; doi:10.1038/s41591-024-03273-3 (https://www.nature.com/articles/s41591-024-03273-3)Cardiology trials continue to under-represent certain population groups relative to disease distribution; this Perspective outlines strategies to foster representativeness and create a research enterprise that meets the needs of people living with cardiovascular disease.

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Nature Medicine

14 Oct, 16:32

A chatbot changes the minds of conspiracy theorists
https://www.nature.com/articles/d41591-024-00073-7

Nature Medicine, Published online: 14 October 2024; doi:10.1038/d41591-024-00073-7 (https://www.nature.com/articles/d41591-024-00073-7)A study of over 2,000 people shows that interacting with a large language model reduced belief in conspiracy theories — including some related to COVID-19 — by providing tailored, one-on-one interactions and compelling evidence.

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Nature Medicine

12 Oct, 11:38

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Nature Medicine

11 Oct, 16:04

Putting children’s safety at the heart of violence research
https://www.nature.com/articles/s41591-024-03291-1

Nature Medicine, Published online: 11 October 2024; doi:10.1038/s41591-024-03291-1 (https://www.nature.com/articles/s41591-024-03291-1)Research and interventions where children may disclose violence require effective, resourced and context-specific safeguarding response plans.

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Nature Medicine

11 Oct, 16:03

Lassa vaccines to save lives, spare economies and assist in pandemic preparedness
https://www.nature.com/articles/s41591-024-03332-9

Nature Medicine, Published online: 11 October 2024; doi:10.1038/s41591-024-03332-9 (https://www.nature.com/articles/s41591-024-03332-9)Lassa fever is a cryptic viral disease that is spread predominantly from rodents to humans in West Africa. We estimated the health-economic burden associated with Lassa fever, highlighting the gains to population health and economies that could be afforded by Lassa vaccines, several of which are currently in development.

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Nature Medicine

10 Oct, 10:28

Computational brain models map diversity embedded in aging and dementia
https://www.nature.com/articles/s41591-024-03318-7

Nature Medicine, Published online: 10 October 2024; doi:10.1038/s41591-024-03318-7 (https://www.nature.com/articles/s41591-024-03318-7)This study explored how diverse factors including neurocognitive disorders, socioeconomic inequalities, pollution and gender disparities influence brain aging in underserved populations (groups with limited access to essential services such as healthcare and education). Using deep learning on EEG and fMRI data, we identified brain-age gaps as key markers of accelerated brain aging and their connections to macrosocial determinants of health.

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Nature Medicine

09 Oct, 12:20

AAV gene therapy for Duchenne muscular dystrophy: the EMBARK phase 3 randomized trial
https://www.nature.com/articles/s41591-024-03304-z

Nature Medicine, Published online: 09 October 2024; doi:10.1038/s41591-024-03304-z (https://www.nature.com/articles/s41591-024-03304-z)The primary report of the EMBARK phase 3 trial, testing the AAV-based gene therapy delandistrogene moxeparvovec in Duchenne muscular dystrophy, did not meet its primary endpoint of improvement in NSAA mobility scores compared to placebo. Secondary endpoints show that the therapy was safe and associated with improvements in micro-dystrophin expression and in individual mobility scores.

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Nature Medicine

09 Oct, 12:19

People with cardiac pacemakers require multidisciplinary care
https://www.nature.com/articles/s41591-024-03296-w

Nature Medicine, Published online: 09 October 2024; doi:10.1038/s41591-024-03296-w (https://www.nature.com/articles/s41591-024-03296-w)Echocardiographic screening during routine pacemaker checkups identifies pacing-induced cardiomyopathy in more than one-third of patients, requiring multidisciplinary, guideline-directed follow-up care.

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Nature Medicine

09 Oct, 12:18

Lessons from a negative gene therapy trial for Duchenne muscular dystrophy
https://www.nature.com/articles/s41591-024-03316-9

Nature Medicine, Published online: 09 October 2024; doi:10.1038/s41591-024-03316-9 (https://www.nature.com/articles/s41591-024-03316-9)Delandistrogene moxeparvovec received FDA approval after a negative trial, which highlights the many complexities and challenges of drug development in this setting.

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