A 40-year-old man presents to the clinic with a 2-day history of severe pain, swelling, and redness in his right knee. He reports a fever and difficulty walking due to the pain. His medical history includes diabetes and a recent skin infection near the knee. Examination reveals a hot, swollen, and tender knee joint with a limited range of motion. Synovial fluid aspiration shows turbid fluid with a high white blood cell (WBC) count and Gram-positive cocci on microscopy.
Which of the following statements about septic arthritis is true?
A. Is usually self-limiting
B. Mostly affects a single joint
C. Joint should not be aspirated as it would introduce more infection
D. Blood cultures are mostly negative
E. Leukopenia is common
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