Enteric fever এ কেন Splenomegaly হয়?
Dr. Muhammad Mosleh Uddin
@dr_mosleh
Dr. Muhammad Mosleh Uddin
MBBS (CMC), FCPS part-2 (Cardiology)
Chittagong Medical College & Hospital
Social links:
FB page: https://www.facebook.com/Mosleh.cmc59
Youtube: https://youtube.com/@Dr.Mosleh
Telegram: https:/
Promotional Article for Dr. Muhammad Mosleh Uddin Telegram Channel (English)
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Dr. Muhammad Mosleh Uddin
20 Nov, 10:09
আমার পুরো MBBS life এ কখনোই আমি ভালো রেজাল্ট করতে পারিনি। কখনোই place করার যোগ্যতা হয়নি আমার। তবে হ্যা, আলহামদুলিল্লাহ একবারেই সব প্রফ আল্লাহ তায়ালা পাশ করিয়েছেন। জানার জন্যে পড়তাম, যেকোন কিছু একদম root level থেকে, conception clear করে পড়ার প্রতি আমার ছিল এক অদম্য স্পৃহা আর নেশা। আপনাদের এমন রিভিউ আমাদের স্পৃহাকে আলহামদুলিল্লাহ আরো বাড়িয়ে দেয়, আল্লাহ তায়ালা আপনাদেরকে আরো দূর বহুদূর নিয়ে যাক, আমীন।
Feel the MEDICINE course (medicine full course for 5th year)
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Feel the MEDICINE course (medicine full course for 5th year)
For details https://mediversebd.com/courses/66b7327039f7019ae38afba0
Dr. Muhammad Mosleh Uddin
19 Nov, 08:25
আমরা যখন MALT lymphoma পড়ি তখন একটা term পাই, t(11:18).
এর মানে কী?
A translocation between chromosomes 11 and 18, specifically t(11;18)(q21;q21), is a chromosomal abnormality where segments from these chromosomes exchange places. This particular translocation is notably associated with mucosa-associated lymphoid tissue (MALT) lymphomas, a type of cancer affecting the immune system's lymphoid tissues.
In this translocation, the API2 gene on chromosome 11 fuses with the MALT1 gene on chromosome 18, creating an API2-MALT1 fusion protein. This fusion protein can activate the NF-κB pathway, leading to uncontrolled cell growth and contributing to lymphoma development.
The presence of t(11;18)(q21;q21) varies among MALT lymphomas from different sites:
Lung MALT lymphomas: Approximately 38% exhibit this translocation.
Gastric (stomach) MALT lymphomas: Around 24% are affected.
Conjunctival MALT lymphomas: About 19% show the translocation.
Orbital MALT lymphomas: Approximately 14% have it.
Salivary gland MALT lymphomas: Rarely present, with about 1% occurrence.
Thyroid, skin, and liver MALT lymphomas: The translocation is generally absent.
Clinically, the presence of t(11;18)(q21;q21) in gastric MALT lymphomas is associated with resistance to Helicobacter pylori eradication therapy, indicating that patients with this translocation may require alternative treatments.
Understanding the role of t(11;18)(q21;q21) is crucial for diagnosing and determining the appropriate treatment strategies for MALT lymphomas.
এর মানে কী?
A translocation between chromosomes 11 and 18, specifically t(11;18)(q21;q21), is a chromosomal abnormality where segments from these chromosomes exchange places. This particular translocation is notably associated with mucosa-associated lymphoid tissue (MALT) lymphomas, a type of cancer affecting the immune system's lymphoid tissues.
In this translocation, the API2 gene on chromosome 11 fuses with the MALT1 gene on chromosome 18, creating an API2-MALT1 fusion protein. This fusion protein can activate the NF-κB pathway, leading to uncontrolled cell growth and contributing to lymphoma development.
The presence of t(11;18)(q21;q21) varies among MALT lymphomas from different sites:
Lung MALT lymphomas: Approximately 38% exhibit this translocation.
Gastric (stomach) MALT lymphomas: Around 24% are affected.
Conjunctival MALT lymphomas: About 19% show the translocation.
Orbital MALT lymphomas: Approximately 14% have it.
Salivary gland MALT lymphomas: Rarely present, with about 1% occurrence.
Thyroid, skin, and liver MALT lymphomas: The translocation is generally absent.
Clinically, the presence of t(11;18)(q21;q21) in gastric MALT lymphomas is associated with resistance to Helicobacter pylori eradication therapy, indicating that patients with this translocation may require alternative treatments.
Understanding the role of t(11;18)(q21;q21) is crucial for diagnosing and determining the appropriate treatment strategies for MALT lymphomas.
Dr. Muhammad Mosleh Uddin
18 Nov, 11:04
Lecture Topics: Gastric MALT lymphoma, GIST, Gastroparesis, Esophageal carcinoma.
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এখনই তো সময়, বেসিক কনসেপশন গড়ার, এখনই তো সময়, সবার থেকে এক ধাপ এগিয়ে থাকার ইনশা আল্লাহ…
Feel the MEDICINE course | a complete solution of medicine for 5th year students inshaaa ALLAH.
এখনই তো সময়, বেসিক কনসেপশন গড়ার, এখনই তো সময়, সবার থেকে এক ধাপ এগিয়ে থাকার ইনশা আল্লাহ…
Dr. Muhammad Mosleh Uddin
16 Nov, 18:26
Indication of Erythropoietin (EPO) injection in CKD patients
Dr. Muhammad Mosleh Uddin
16 Nov, 17:28
Feel the MEDICINE course
(medicine full course for 5th year)
Access for 1.5 years
Mentor:
Dr. Muhammad Mosleh Uddin
MBBS (CMC) , FCPS P2 (Cardiology)
Chittagong Medical College & Hospital
Demo lectures link
https://youtube.com/playlist?list=PLXDzN6WdqEQxFaK3qbo1l-07ON-V1JsTP&si=EXh7hybjCAvr8Oeb
For details about the course
https://mediversebd.com/courses/66b7327039f7019ae38afba0
To download the lecture note PDF
https://t.me/mediversebd/3515
(medicine full course for 5th year)
Access for 1.5 years
Mentor:
Dr. Muhammad Mosleh Uddin
MBBS (CMC) , FCPS P2 (Cardiology)
Chittagong Medical College & Hospital
Demo lectures link
https://youtube.com/playlist?list=PLXDzN6WdqEQxFaK3qbo1l-07ON-V1JsTP&si=EXh7hybjCAvr8Oeb
For details about the course
https://mediversebd.com/courses/66b7327039f7019ae38afba0
To download the lecture note PDF
https://t.me/mediversebd/3515
Dr. Muhammad Mosleh Uddin
15 Nov, 18:49
Gastroparesis
Davidson’s এর ছোট একটি প্যারা যদি অমরা বুঝে পড়তে যাই তাহলে কতগুলো info জানতে হয় দেখুন। Conception এর পেছনে দেয়া প্রতিটা minutes আপনার জন্যে investment ইনশা আল্লাহ।
Davidson’s এর ছোট একটি প্যারা যদি অমরা বুঝে পড়তে যাই তাহলে কতগুলো info জানতে হয় দেখুন। Conception এর পেছনে দেয়া প্রতিটা minutes আপনার জন্যে investment ইনশা আল্লাহ।
Dr. Muhammad Mosleh Uddin
14 Nov, 03:58
Alhamdulillah,
"Feel the MEDICINE"
(medicine full course for 5th year)
GIT | Lecture - 7 | Topic: Gastric carcinoma
For registration, please visit here.
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Demo classes:
https://youtube.com/playlist?list=PLXDzN6WdqEQxFaK3qbo1l-07ON-V1JsTP&si=w5rp9VwnR5idWyp0
"Feel the MEDICINE"
(medicine full course for 5th year)
GIT | Lecture - 7 | Topic: Gastric carcinoma
For registration, please visit here.
https://mediversebd.com/courses/66b7327039f7019ae38afba0
Demo classes:
https://youtube.com/playlist?list=PLXDzN6WdqEQxFaK3qbo1l-07ON-V1JsTP&si=w5rp9VwnR5idWyp0
Dr. Muhammad Mosleh Uddin
08 Nov, 17:19
🔷 Case scenario
Patient: John, a 42-year-old male
Presenting Complaint: Progressive weakness and tingling in the legs
History of Present Illness:
John noticed a tingling sensation in his toes and feet about a week ago. He initially thought it was due to fatigue.
Over the past three days, the tingling spread to his calves and started to feel more like numbness.
He now has trouble climbing stairs and reports his legs feel "heavy."
Today, he has difficulty standing and feels weakness in his arms, though less pronounced.
Past Medical History:
Two weeks ago, John had a mild respiratory infection, which resolved on its own.
No significant medical history, no known allergies, and no recent vaccinations.
Physical Examination:
Neurological Exam:
Motor Strength: 3/5 in the lower limbs, 4/5 in the upper limbs.
Reflexes: Absent patellar and Achilles reflexes (hyporeflexia), with decreased reflexes in the arms as well.
Sensory Exam: Reports reduced sensation in the legs.
Cranial Nerves: Intact.
🔴 What is your provisional diagnosis & differentials?
Patient: John, a 42-year-old male
Presenting Complaint: Progressive weakness and tingling in the legs
History of Present Illness:
John noticed a tingling sensation in his toes and feet about a week ago. He initially thought it was due to fatigue.
Over the past three days, the tingling spread to his calves and started to feel more like numbness.
He now has trouble climbing stairs and reports his legs feel "heavy."
Today, he has difficulty standing and feels weakness in his arms, though less pronounced.
Past Medical History:
Two weeks ago, John had a mild respiratory infection, which resolved on its own.
No significant medical history, no known allergies, and no recent vaccinations.
Physical Examination:
Neurological Exam:
Motor Strength: 3/5 in the lower limbs, 4/5 in the upper limbs.
Reflexes: Absent patellar and Achilles reflexes (hyporeflexia), with decreased reflexes in the arms as well.
Sensory Exam: Reports reduced sensation in the legs.
Cranial Nerves: Intact.
🔴 What is your provisional diagnosis & differentials?
Dr. Muhammad Mosleh Uddin
08 Nov, 14:40
সব breathlessness সাধারণত lying postition এ বেড়ে যায় হোক সেটা cardiac cause or lung cause.
কিন্তু একটা breathlessness আছে sitting or standing position এ বেড়ে যায়। Lying position এ কমে। এটা হলো Hepatopulmonary syndrome.
কিন্তু একটা breathlessness আছে sitting or standing position এ বেড়ে যায়। Lying position এ কমে। এটা হলো Hepatopulmonary syndrome.
Dr. Muhammad Mosleh Uddin
08 Nov, 14:32
🔷 CLD তে Pulmonary arterial pressure বাড়তেও পারে, আবার কমতেও পারে।
🔷Hepatopulmonary syndrome:
Chronic liver disease (CLD) এর একটা complication হলো Hepatopulmonary syndrome যেখানে Pulmonary arterial pressure কমে।
🔷 Portopulmonary hypertension:
এখানে itself Liver pathology এর জন্যে pulmonary arterial pressure বাড়ে অর্থাৎ Pulmonary hypertension develop করে। এই Pulmonart HTN টা lung pathology অর্থাৎ Obstructive airways disease এর জন্যে হয়না।
যেটাকে আমরা প্রায়ই Cor Pulmonale বলে misdiagnosed করি।
Dr. Muhammad Mosleh Uddin
MBBS (CMC), FCPS P2 (Cardiology)
Chittagong Medical College & Hospital
🔷Hepatopulmonary syndrome:
Chronic liver disease (CLD) এর একটা complication হলো Hepatopulmonary syndrome যেখানে Pulmonary arterial pressure কমে।
🔷 Portopulmonary hypertension:
এখানে itself Liver pathology এর জন্যে pulmonary arterial pressure বাড়ে অর্থাৎ Pulmonary hypertension develop করে। এই Pulmonart HTN টা lung pathology অর্থাৎ Obstructive airways disease এর জন্যে হয়না।
যেটাকে আমরা প্রায়ই Cor Pulmonale বলে misdiagnosed করি।
Dr. Muhammad Mosleh Uddin
MBBS (CMC), FCPS P2 (Cardiology)
Chittagong Medical College & Hospital
Dr. Muhammad Mosleh Uddin
06 Nov, 15:37
আসসালামুয়ালাইকুম ওয়া রহমাতুল্লাহ
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For registration please visit our website for details
https://mediversebd.com/courses/66b7327039f7019ae38afba0
"Feel the MEDICINE"
(Medicine Full Course For Final Prof & Onwards)
ইনশা আল্লাহ, আপনাদের জন্যে এক অন্যরকম journey হবে আমার এই highly dedicated course টা ইনশা আল্লাহ।
For registration please visit our website for details
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