1. Drugs that cause or aggravate bronchial asthma:
• B-Blockers.
• Aspirin and other NSAIDs.
• Tamoxifen.
• Dipyridamole.
• Nebulized pentamidine: used for the treatment of Pneumocystis carinii (Pneumocystis jiroveci)
infection.
2. Drugs that cause cough:
• ACE inhibitors (e.g., Lisinopril, ramipril. More in females, actual mechanism is unknown).
This drug causes conversion of angiotensin-1 to angiotensin-2. Also, causes breakdown of
bradykinin and substance P. All these may cause cough.
3. DPLD (non-eosinophilic alveolitis):
• Busulphan.
• Bleomycin.
• Methotrexate.
• Amiodarone.
• Nitrofurantoin.
• Azathioprine.
4. Pulmonary eosinophilia:
• Antibiotics (sulphonamide, penicillin, tetracycline, nitrofurantoin).
• Anti-rheumatic agent (gold, aspirin, penicillamine, naproxen).
• Anti-convulsant (phenytoin, carbamazepine).
• Anti-depressant or antipsychotic (imipramine, chlorpromazine, dothiepin).
• Cytotoxic (methotrexate, bleomycin, procarbazine).
5. Adult respiratory distress syndrome (ARDS):
• Aspirin and opium (in overdose).
• Streptokinase.
• Hydrochlorothiazide.
6. Pleural disease or effusion:
• Bromocriptine.
• Nitrofurantoin.
• Methotrexate.
• Methysergide.
• By SLE (hydralazine, INH, procainamide, phenytoin, carbamazepine, chlorpromazine).
7. Mediastinal widening or hilar lymphadenopathy (pseudolymphoma):
• Phenytoin or diphenylhydantoin.
8. Respiratory failure:
• Opium.
• Sedative or hypnotic.
• Alcohol.
• Tricyclic antidepressant.