Pharmacology

Correct Answer -C
Ans. is 'c' i.e., It does not cause alopecia
Vincristine belongs to the plant alkaloid group of anticancer
* Useful for inducing remission in childhood ALL (not useful in
maintenance therapy)
* It can also be used for pediatric solid tumors (Wilm's tumor,
neuroblastoma, rhabdomyosarcoma) and lymphomas
* Prominent adverse effects?
* Peripheral neuropathy
Alopecia
SIADH

Correct Answer -D

Correct Answer -C
Ans. is 'c' i.e., Pyrimethamine
○ Antimalarials that act on erythrocytic phase of schizogony are
called erythrocytic schizontocides. The available drugs can be
divided into?
1. Fast acting - Chloroquine, amodiaquine, quinine, mefloquine,
halofantrine, lumefantrine, atovaquone, artemisinin.
2. Slow acting - Pyrimethamine, Proguanil, sulfonamides
tetracyclines.

Ans. is 'a' i.e., Vancomycin
Vancomycin can cause red men syndrome

Correct Answer - A
Ans. is 'a' i.e., Used in DLE
○ Clofazimine interferes with template function of DNA, is used in
lepra reaction and can cause icthyosis and hyperpigmentation

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Correct Answer - A
Ans. is 'a' i.e., Entecavir
○ Entecavir is the DOC for chronic hepatitis B infection

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Ans. is 'c' i.e., Moxalactam
○ Ceftriaxone, cefoperazone, moxalactam & cefamandole can cause
hypoprothrmbinemia and bleeding

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Correct Answer - B
Ans. is 'b' i.e., Amikacin

Correct Answer
Q
Ans. is 'c' i.e., Moxalactam
○ Ceftriaxone, cefoperazone, moxalactam & cefamandole can cause
hypoprothrmbinemia and bleeding.

Correct Answer - B
Ans. is 'b' i.e., Diarrhea
Cisapride is a prokinetic agent and often produces loose stools
(diarrhea is thus the commonest side effect)

Correct Answer - D D i.e. Ischemic heart disease Ketamine causes profound analgesiaQ, disociative anesthesiaQ, and emergence psychomimetic hallucinations and delirium Q: Ketamine increases cerebral metabolism, 02 consumption, blood
flow & intracranial pressure.Q
Ketamine
* It causes profound analgesiaQ and dissociative anesthesiaQ (i.e. patient appears conscious e.g. eye opening, swallowing but unable to process or respond to sensory input). Ketamine causes Dissociative AnesthesiaQ by acting on cortex and subcortical areas (not on RAS) It feeling of dissociation from ones own body and surroundings. Post Operative Delirium and HallucinationQ is part of this Dissociative phenomenon. Drug of choice for post op. delirium & hallucination is Lorazepam.Q * It is closest to being a complete anesthetic since it induces analgesia, amnesia & unconsciousness * It iS associated with emergence psychotomimetic side effects (delirium, illusions, hallucination)@. It is less common in children and pretreatment with lorazepam (drug of choice)Q.

Correct Answer-D Ans. is 'd' i.e., Beta-2 receptor stimulation Proposed mechanisms of action of theophylline • Phosphodiesterase inhibition (Non selective) • Adenosine receptor antagonism (A1, A2) • Increased histone Deacetylase activity (tred efficacy of corticosteroids) • Inhibition of intracellular calcium release • Sstimulation of catecholamine release • Inhibition of NF - alpha Beta translocation into the nucleus (nuclear translocation) • Mediator inhibition (Prostaglandins, TNF alpha)

Correct Answer-A Ans. is 'a' i.e., Infiltration anaesthesia ○ Infiltration anaesthesia is the injection of local anaesthetic directly into tissue without taking into consideration the course of cutaneous nerve.

Ans is c
Mivacurium

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[9.2] A 59-year-old man is admitted to the intensive care unit for a myocar- dial infarction. He is given a ẞ-adrenergic antagonist and instructed to avoid emotional turmoil to decrease sympathetic stimulation of the heart. From a cellular perspective, sympathetic stimulation of the heart does which of the following?