Patho pearls 🔬🐼

HLA allele & Disease Association

✅HLA A3 : Hemochromatosis


✅HLA B8 : Myasthenia Gravis ,Graves disease

✅HLA B16 : Multiple sclerosis


✅HLA B27:
Ankylosing spondylitis, Acute anterior uveitis
Reactive arthritis,Psoriatic
arthritis

✅HLA B47: Congenital adrenal hyperplasia

✅HLA B51 : Behcet's disease

✅HLA B57: Abacavir Hypersensitivity

✅HLA CW6 : Psoriasis

✅HLA DQ1: Narcolepsy

✅HLA DQ 2 : Celiac disease

✅HLA DR2 : SLE(Japanese) & Sjogren Syndrome


✅HLA DR3 : Type I diabetes mellitus,Dermatitis herpetiformis,
Chronic active hepatitis,
Sjogren's syndrome ,SLE (white)

✅HLA DR4 : Rhematiod Arthritis

✅HLA DR5 : Pernicious Anemia , Hasimoto's Thyroiditis

✅HLA DR8 ,DR5 : juvenile arthritis ( pauci articular)

1. Damage to nervous tissue is repaired by : Neuroglia

2. Mycosis fungoides : Cutaneous lymphoma

3. Secondary amyloidosis complicates: Chronic osteomyelitis

4. The earliest feature of TB is: Lymphocytosis

5. The low grade non-hodgkins lymphoma is : Follicular

6. Liquefactive necrosis is seen in : Brain

7. The crescent forming glomerulonephritis is: RPGN

8. Earliest feature of correction of IDA is : Reticulocytosis

9. Kupffer's cells are found in : Liver

10. Heart failure cells are found in : Lungs

11. Psammoma bodies show: Dystrophic calcification


12. Beta-microglobulin: is not a tumor marker

13. Commonest benign tumor of liver : Hemangioma

14. Blood when stored at 4 degree celcius can be kept for: 21 days

15. Congo-red with amyloid produces: Brilliant pink ccolour

16. Cloudy swelling does not occurs in : Lungs

17. Gamma Gandy bodies contains hemosiderin and : Ca++

18. Hutchinson's secondaries in skull are due to tumors in : Adrenals

19. Albumino -cytologic dissociation occurs in cases of: Guillain Barre syndrome

20. Metastatic calcification is most often seen in : Lungs

21. ASLO Titres are used in the diagnosis of: Acute rheumatic fever

22. Apoptosis is inhibited by : bcl-2

23. CEA: is not used as a tumor marker in testicular tumours

24. Onion peel appearance of splenic capsule is seen in : SLE

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