Certainly! Below is the matching of systemic diseases with their respective rheumatic manifestations:
1. Hypertrophic Osteoarthropathy (HOA):
• Disease: Lung cancer, lung fibrosis, cirrhosis, other tumors
• Rheumatic Manifestation: Long bone periostitis with clubbing of fingers and toes, mainly affecting distal ends of long bones, pain and swelling (no inflammation).
2. Leukemia and Lymphoma:
• Leukemia:
• Rheumatic Manifestation: Synovitis, bone pain, symmetrical arthritis, and oligoarthritis (6% of adults present with rheumatic symptoms before diagnosis).
• In Children: 60% present with mono or polyarthritis.
• Lymphoma:
• Rheumatic Manifestation: Bone pain, rare arthritis.
3. Hemophilia:
• Disease: Factor 8 (Type A) or Factor 9 (Type B) deficiency
• Rheumatic Manifestation: Hemarthrosis (bleeding into joints), chronic arthropathy, degenerative arthritis.
• Treatment: Factor replacement therapy, ice, corticosteroids, rest, physiotherapy.
4. Sickle Cell Disease and Thalassemia:
• Sickle Cell Disease:
• Rheumatic Manifestation: Painful crises, arthropathy, osteonecrosis, dactylitis, osteomyelitis, arthritis (big joints), non-inflammatory synovial fluid, septic arthritis (most often Salmonella).
• Thalassemia:
• Rheumatic Manifestation: Osteoporosis, pathological fractures, epiphyseal deformities, non-inflammatory arthritis in thalassemia minor.
5. Multiple Myeloma and Amyloidosis:
• Multiple Myeloma:
• Rheumatic Manifestation: Bone pain, lytic bone lesions, pathological fractures, osteoporosis.
• Amyloidosis:
• Rheumatic Manifestation: Symmetrical small joint polyarthritis (resembles RA), amyloid deposits causing deformities (e.g., shoulder pad sign).
• Diagnosis: Congo red staining showing apple-green birefringence.
• Secondary form (AA type): Resulting from chronic diseases like RA, IBD, tuberculosis.
6. Whipple Disease:
• Disease: Tropheryma whipplei infection
• Rheumatic Manifestation: Intermittent, migratory oligoarthritis, inflammatory synovial fluid with increased mononuclear cells.
• Treatment: Antibiotic therapy (tetracycline), complete remission within 1 week to 1 month.
7. Hemochromatosis:
• Disease: Iron deposition disease
• Rheumatic Manifestation: Symmetrical arthritis in 2nd-3rd MCP joints, osteoarthritis-like changes, chondrocalcinosis.
• Diagnosis: Identifying mutant gene sequence in peripheral blood.
8. Endocrine Diseases:
• Diabetes Mellitus:
• Rheumatic Manifestation: Carpal tunnel syndrome (CTS), adhesive capsulitis, Charcot joint, cheiroarthropathy, diabetic muscle infarction.
• Hypothyroidism:
• Rheumatic Manifestation: Proximal myopathy, arthralgia, joint effusion, CTS, chondrocalcinosis.
• Hyperthyroidism:
• Rheumatic Manifestation: Myopathy, osteoporosis, thyroid acropachy.
• Hyperparathyroidism:
• Rheumatic Manifestation: Myopathy, arthralgia, erosive arthritis, chondrocalcinosis.
• Hypoparathyroidism:
• Rheumatic Manifestation: Muscle cramps, soft tissue calcification, spondyloarthropathy.
• Acromegaly:
• Rheumatic Manifestation: CTS, myopathy, Raynaud’s phenomenon, back pain, premature osteoarthritis.
• Cushing’s Syndrome:
• Rheumatic Manifestation: Myopathy, osteoporosis, avascular necrosis.
This matching pairs the diseases with their respective rheumatic manifestations, keeping the full details you provided intact. Let me know if you need any further adjustments!