Dr John B. @drjohnb Channel on Telegram

Dr John B.

@drjohnb

Scientist, lecturer & father | Whistleblower

Dr John B. (English)

Are you fascinated by science and eager to learn from a knowledgeable and experienced individual? Look no further than Dr John B.'s Telegram channel! Dr John B. is not just a scientist but also a dedicated lecturer and a loving father. With a diverse background in various fields of science, he shares his expertise and insights with his audience on his channel

Dr John B.'s channel is a hub for those who are interested in cutting-edge research, groundbreaking discoveries, and thought-provoking discussions on various scientific topics. He doesn't shy away from controversial subjects and is known for being a whistleblower when it comes to exposing the truth in the scientific community

Whether you are a student looking to expand your knowledge, a science enthusiast seeking engaging content, or simply someone who appreciates the value of scientific discourse, Dr John B.'s channel has something for everyone. Stay updated on the latest developments in the world of science, get inspired by his insightful lectures, and join a community of like-minded individuals who share a passion for learning and discovery. Subscribe to Dr John B.'s Telegram channel today and unlock a world of scientific exploration and enlightenment!

Dr John B.

05 Jan, 21:19

Will we all soon be indirectly vaccinated by eating meat?
In France, a self-amplifying mRNA vaccine is now being used in the factory farming of ducks.
Helene Banoun (@BanounHelene) has published an important article on the subject: https://tinyurl.com/285hwx6u

- "The CEVA vaccine is a self-amplifying mRNA encoding H5 of H5N8 coated in ferric nanoparticles, and contains squalene (suspected of toxicity in humans)."

- "When ducks are vaccinated with CEVA's self-amplifying mRNA product, it must be emphasized that no tests have been carried out on the ability of this gene product to be transmitted to the duck meat consumer."
81,615
Dr John B.

05 Jan, 08:58

Neuro-Sjögren's syndrome (SS) in a 34-year-old woman 9 months after she received her third dose of COVID-19 vaccination -> https://www.cureus.com/articles/287454-new-onset-of-neuro-sjgrens-syndrome-nine-months-after-the-third-covid-19-vaccine-dose-a-case-report#!/

SS: an autoimmune chronic inflammatory disease causing peripheral nerve system and central nervous system issues.

- "The present case report is about a 34-year-old woman who presented with progressive numbness, difficulty in walking, and blurred vision following the COVID-19 vaccine booster, but she never had COVID-19 or any infection."

- "This case highlights the need for increased vigilance and research into vaccine-induced autoimmunity."
5,849
Dr John B.

05 Jan, 07:48

Increased risk of ischemic stroke within 1-42 days after the coadministration of the Pfizer-BioNTech bivalent COVID-19 vaccine and influenza vaccine:
https://publichealth.jmir.org/2024/1/e53807

"The potential association between bivalent vaccination and ischemic stroke in the 1-42–day analysis warrants further investigation among individuals younger than 65 years with influenza vaccine coadministration and prior SARS-CoV-2 infection. Furthermore, the findings on ischemic stroke risk after bivalent COVID-19 vaccination underscore the need to evaluate monovalent COVID-19 vaccine safety during the 2023-2024 season."
8,682
Dr John B.

05 Jan, 07:32

COVID-19 mRNA vaccines are associated with higher incidence of adverse events compared to other vaccines
-> https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full
6,603
Dr John B.

05 Jan, 07:27

"Activation and differentiation of T cells into effector cells are thought to rely on three signals received from antigen-presenting cells (APCs), such as dendritic cells (DCs). The first signal is in the form of peptide-MHC, the second signal is membrane-bound co-stimulation, and the third signal is in the form of soluble cytokines. If the T cells receive the third signal before the first one, it is called out-of-sequence stimulation, which can lead to the T cells’ death or render them anergic and non-responsive (136, 137). Exposure to mRNA-LNP or LNP leads to a rapid release of inflammatory cytokines (12), including type I interferons (7) that are known to induce out-of-sequence stimulation, which likely exposes the adaptive immune cells, including the T cells, to an inflammatory environment before the mRNA is translated into protein and presented on DCs. Thus, with a high likelihood, one of the potential flaws of the mRNA-LNP platform, unlike the old-school vaccines where the antigen presentation and inflammation coincide, is that it exposes the adaptive immune cells to an out-of-sequence stimulation, which might worsen upon further exposure."
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full
5,844
Dr John B.

05 Jan, 07:27

Another mechanism by which the COVID-19 vaccines can lead to a systemic weakening of the immune system: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1336906/full
An "out-of-sequence stimulation" is triggered.

- "... these data suggest that the inflammatory environment created by the LNPs is detrimental to naïve T cells."

"... the observed changes were likely systemic since the direct draining organs, the skin-draining lymph nodes, and the distant spleen showed similar trends."

"These data align with our previous findings that exposure to mRNA-LNP or LNP leads to systemic inhibition of adaptive immune responses."

"... it exposes the adaptive immune cells to an out-of-sequence stimulation, which might worsen upon further exposure."
15,171
Dr John B.

03 Jan, 20:30

The SARS-CoV-2 spike protein induces a prolonged vascular inflammatory effect on human endothelial cells -> https://link.springer.com/article/10.1007/s10753-024-02208-x

"... SARS-CoV-2 spike resulted in sustained inflammation, changes in antigen presentation, and coagulation state of the endothelium. The observed prolonged effects beyond the presence of the spike protein suggests possible long-term consequences of SARS-CoV-2 on the endothelium."
8,784
Dr John B.

03 Jan, 20:13

Kawasaki disease in a 2-month-old boy 5 days after receiving the DTwP-HepB-Hib (5-in-1) vaccine
-> https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-024-04987-1
Kawasaki disease: an acute inflammatory disorder primarily affecting medium-sized blood vessels.

"Early diagnosis and timely intervention are essential to prevent severe complications, such as coronary artery aneurysms and possible mortality. It underscores the need for heightened awareness and vigilance among healthcare providers in similar clinical scenarios."
4,971
Dr John B.

03 Jan, 17:09

Bullous pemphigoid (BP) (an autoimmune blistering disease) 4 days after vaccination (DPT, polio, hepatitis B, Haemophilus influenzae type b, whooping cough, rotavirus, and pneumococcal vaccines) and after a 7-day flucloxacillin course
-> https://www.cureus.com/articles/322380-bullous-pemphigoid-onset-following-vaccination-in-infancy-a-case-report#!/
Case of a 4 month-old infant.

"Future research should focus on analysing the routes through which vaccinations modulate the immune system since these may increase the risk of autoimmune diseases ..."
8,604
Dr John B.

03 Jan, 16:15

Case of a 19 year-old woman experiencing significant breast hypertrophy starting 1 week after receiving the Pfizer COVID-19 vaccine in September 2022.
"The patient initially reported tingling paresthesia in her breasts, followed by sudden bilateral growth which worsened after receiving the second vaccine dose. Over 6 months, her breast size increased from a B cup to a triple G."
-> https://journals.lww.com/prsgo/fulltext/2024/12000/the__pfizer_boob_job___a_case_of_unexplained.52.aspx

"The association between the COVID-19 vaccine, PASH, and breast hypertrophy warrants further investigation to comprehend the spectrum of reactions to the vaccine."
15,019
Dr John B.

03 Jan, 11:09

The mRNA COVID-19 vaccine is contaminated with DNA. This has been confirmed by yet another study, which was a high school science project conducted in an FDA laboratory and supervised by FDA scientists -> https://jhss.scholasticahq.com/article/127890-a-rapid-detection-method-of-replication-competent-plasmid-dna-from-covid-19-mrna-vaccines-for-quality-control

- Residual DNA was detected in 6 vials of two different batches of Pfizer COVID-19 mRNA vaccines. - The DNA levels exceeded the safety limits by 6 to 470 times!

The use of mRNA COVID-19 vaccines should be stopped immediately!
18,868
Dr John B.

23 Dec, 07:58

New study
Changing epidemiology of myocarditis in Australia: A population-nased cohort study:
https://www.mdpi.com/2077-0383/13/23/7111
Analyzed data: 2001-2022

"There was an inflexion point in 2021 during which the growth rate in the incidence of myocarditis accelerated. By 2022, the incidence of myocarditis was about 8 cases per-100,000 with no sign of slowing."

"The current study underlines the rising incidence of myocarditis, especially post-pandemic."

I am wondering about this sharp increase in cases of myocarditis. What could be the reason? Any ideas? ...
23,926
Dr John B.

23 Dec, 07:40

SARS-CoV-2 vaccine-associated liver injury (SVALI):
https://onlinelibrary.wiley.com/doi/10.1111/liv.16209
- "The heterogeneous clinical entity of acute liver injury linked to SARS-CoV-2 vaccines includes patients requiring long-term immunosuppression, similarly to autoimmune hepatitis, and patients with self-limiting liver damage, possibly representing a unique form of autoimmune-like hepatitis, which we suggest being referred to as SARS-CoV-2 vaccine-associated liver injury (SVALI)."
- "Further studies are needed to investigate the pathogenic mechanisms related to the immune response to the spike viral protein in the liver."
7,166
Dr John B.

23 Dec, 07:31

Kounis syndrome following COVID-19 vaccination: https://www.tandfonline.com/doi/10.1080/21645515.2024.2365496?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#abstract
Kounis syndrome: "an acute coronary syndrome triggered by allergic mediators that induce coronary vasoconstriction and thrombosis, leading to further myocardial damage and anaphylactic shock."

- "Most patients developed clinical manifestations associated with Kounis syndrome within 2 hours of vaccination and progressed rapidly."
6,367
Dr John B.

23 Dec, 07:13

Optic neuritis & short-segment myelitis following ChAdOx1 adenovirus COVID-19 vaccination: https://journals.lww.com/neur/fulltext/2024/11000/optic_neuritis_and_short_segment_myelitis.28.aspx
- "Magnetic resonance imaging of the brain showed T2/FLAIR hyperintensity of the right optic nerve. The middle portion of the right optic nerve showed mild enhancement."
- "MRI of the spinal cord demonstrated a short-segment T2/FLAIR hyperintensity in the cervicothoracic region" (-> small vessel spinal cord strokes)
5,155
Dr John B.

23 Dec, 07:05

https://link.springer.com/article/10.1007/s12026-024-09553-x#Sec7
"The vaccines imposed severe potential health side effects such as clotting or obstruction of blood vessels termed arterial or venous thrombosis, autoimmune damage of nerve cells (Guillain-Barré syndrome; GBS), intense activation of coagulation system (vaccine-induced thrombotic thrombocytopenia), acute ischemic stroke (AIS) and cerebral venous sinus thrombosis (CVST), myocarditis, pericarditis, and glomerular disease."

- "It is essential to continue rigorous follow-up and surveillance studies to monitor vaccine safety and identify potential risks, particularly in immunocompromised individuals, those with comorbidities, and other vulnerable populations."
- "Long-term data on vaccine interactions, effects during pregnancy, and implications for individuals with autoimmune or inflammatory conditions are still needed."
13,001
Dr John B.

23 Dec, 06:59

Syncopes, paresis & loss of vision after COVID-19 mRNA-based vaccination & SARS-CoV-2 infection: https://link.springer.com/article/10.1007/s15010-024-02439-y
- "6 h after vaccination, the patient developed severe cephalgia & dizziness lasting for several days"
- "Spontaneous syncope occurred 20–30 times over the following 2 weeks. Even though the syncopes disappeared, the patient continued to observe irregular heartbeats. ... he reported new onset of fatigue, brain fog, acral paresthesia, paresis of forearm extensors and Mm. quadriceps femoris, disseminated fasciculations & urticaria in the weeks following the vaccination"
- "143 days after vaccination, the patient suffered a PCR confirmed SARS-CoV-2 infection, and the symptoms experienced after vaccination exacerbated"
- "The details on the mechanisms underlying adverse side effects caused by mRNA-based vaccines remain unclear"
- "Further mechanistic research assessing the pathologies that may trigger mRNA vaccine-associated symptoms are urgently needed"
5,659
Dr John B.

01 Dec, 20:52

In Germany, there is now a laboratory where you can get tested to see if you have components of the mRNA vaccine in your body (blood, tissue samples, etc.).
-> https://inmodia.de/en/

The Institute of Molecular Diagnostics (INMODIA GmbH) offers detection of:
- Spike protein
- ‘Vaccine mRNA’ (modRNA)
- Contaminating DNA (plasmid DNA)
These components can be detected in the following sample materials:
- Tissue samples (biopsy or autopsy materials, fixed or unfixed)
- Blood plasma
- Cerebrospinal fluid
- Immune cells from whole blood or cerebrospinal fluid

It's great that a service like this is now available!
I expect that many more such laboratories will be opened worldwide in the near future, or that existing laboratories will start offering these services...
30,895
Dr John B.

01 Dec, 19:31

(7/n)
Systematic studies are now needed to investigate these large clots using ThT-based fluorescence microscopy and, ideally, staining of NETs, as well as quantification of the amyloid fibrin microclot concentration (and size distribution) in plasma.
This would actually be a topic for a @Nature or @ScienceMagazine paper – which research group dares to tackle this hot and difficult topic?
For an earlier analysis of these clots, see my older post: https://x.com/DrJohnB2/status/1807188321665212922
15,274
Dr John B.

01 Dec, 19:30

(6/n)
The fact that these clots stain positive for ThT is not good news, as it indicates that these clots are special and cannot be easily dissolved by the body through fibrolysis.
Presumably, these clots are also full of neutrophil extracellular traps (NETs), as has already been shown for amyloid-fibrin microclots (which are probably the smaller form of these macroclots) [1]:
[1] https://www.researchsquare.com/article/rs-4666650/v1
19,185
Dr John B.

01 Dec, 19:30

(5/n)
5,357
Dr John B.

01 Dec, 19:29

(4/n)
5,386
Dr John B.

01 Dec, 19:29

(3/n)
5,378
Dr John B.

01 Dec, 19:29

(2/n)
5,569
Dr John B.

01 Dec, 19:29

(1/n)
Important discovery regarding the special thrombi (clots) observed by various embalmers and pathologists: staining with the sensitive amyloid dye Thioflavin T (ThT) is positive, i.e. they are probably amyloid-like thrombi!
Here are fluorescence microscopy images published by Richard Hirschman (@r_hirschman) and Greg (@Greg21143362):
17,446
Dr John B.

27 Nov, 21:00

45 cases of thrombosis with thrombocytopenia syndrome after COVID-19 vaccination:
https://www.elsevier.es/es-revista-neurologia-english-edition--495-avance-resumen-thrombosis-with-thrombocytopenia-syndrome-following-S2173580824000828
"One-quarter of patients died, and increased risk of death was associated with severe thrombocytopenia and presence of intracranial haemorrhage."
11,703
Dr John B.

27 Nov, 20:43

"... our MR study provides evidence supporting a causal relationship between COVID-19 vaccination and ischemic stroke."
-> https://www.strokejournal.org/article/S1052-3057(24)00556-1/fulltext
12,567
Dr John B.

27 Nov, 20:28

The plasmid DNA contained in mRNA vaccines can integrate into the genome of normal cells!
Important experimental work by Prof. Buckhaults.
https://x.com/P_J_Buckhaults/status/1861083163868672204
18,817
Dr John B.

25 Oct, 05:59

Matrix metalloproteinase-9 (MMP-9) is significantly elevated in the serum of long COVID patients:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11472557/
- Microglia release MMP-9 when stimulated by SARS-CoV-2 Spike protein
- "MMP-9 can disrupt the polysaccharide scaffolding of the brain matrix & digest tight junction proteins, thus disrupting neuronal connectivity. MMP-9 can cause vascular inflammation and increase blood brain barrier (BBB) permeability"
(The COVID-19 vacciantion status of the study participants was not taken into account)
(An increase in MMP-9 has been documented in patients with systemic inflammation following COVID-19 vaccination: https://journals.lww.com/jcma/fulltext/2023/09000/elevated_serum_levels_of_t_cell_immunoglobulin_and.8.aspx)
12,778
Dr John B.

25 Oct, 05:38

Normocomplementemic urticarial vasculitis (UV) following influenza vaccination: https://www.dovepress.com/normocomplementemic-urticarial-vasculitis-following-influenza-vaccinat-peer-reviewed-fulltext-article-IMCRJ
"The exact mechanism underlying the development of UV following vaccination remains unclear."
"Accumulation of further cases and research is required to investigate the clinical course and underlying mechanisms of vaccine-induced UV."
10,412
Dr John B.

25 Oct, 05:32

Secondary T-cell deficiency (particularly affecting CD4 T cells) & chronic spontaneous urticaria after COVID-19 vaccination: https://www.jaci-global.org/article/S2772-8293(24)00135-8/fulltext
- "The precise mechanism underlying this occurrence remains unknown, although there have been numerous reports highlighting the association between COVID-19 vaccination and autoimmune disorders."
- During his treatment period, he received another COVID-19 vaccine, got COVID-19, and the doctors administered additional vaccines (pneumococcal conjugate vaccine 13-valent, herpes zoster vaccine, pneumococcal polysaccharide vaccine 23-valent, and diphtheria, tetanus, and pertussis vaccine) "to prevent further complications."
8,248
Dr John B.

23 Oct, 19:32

Otitis media with ANCA-associated vasculitis following COVID-19 mRNA vaccination -> https://pubmed.ncbi.nlm.nih.gov/39344100/
"The pathogenesis of adverse events following COVID-19 vaccination are still unclear. This report has indicated that ANCA-associated vasculitis can be related to COVID-19 mRNA vaccines. As our knowledge of autoimmune disease developing after COVID-19 vaccination is still in the accumulation phase, it is relevant to amass such case reports and use them for assistance in diagnosis in the future."
15,236
Dr John B.

23 Oct, 19:27

Type 1 diabetes mellitus caused by COVID-19 mRNA vaccination: A case report and literature review of 17 published cases
-> https://pmc.ncbi.nlm.nih.gov/articles/PMC11447533/

"New-onset type 1 DM has been reported after COVID-19 mRNA vaccination. Clinicians should maintain a high index of suspicion and pursue early testing for the same to reduce adverse outcomes and improve long-term prognosis."
10,333
Dr John B.

23 Oct, 19:24

Guillain Barré Syndrome (GBS) 4 weeks after receiving the COVID-19 vaccine -> https://pmc.ncbi.nlm.nih.gov/articles/PMC11457283/
Case of a 66-year-old woman.
She died.
"Despite the treatment, a deterioration of respiratory function led the patient to premature mortality."
10,931
Dr John B.

23 Oct, 19:14

Multisystem inflammatory syndrome in an adult after Covid-19 vaccination (MIS-V) -> https://jpma.org.pk/index.php/public_html/article/view/9092
Case of a 67-year-old woman.
She died.
"The patient's complex presentation and unfortunate outcome highlight the challenges in managing such cases ..."
7,794
Dr John B.

23 Oct, 19:06

New onset of neuro-Sjögren's syndrome 9 months after the 3rd COVID-19 vaccine dose -> https://pmc.ncbi.nlm.nih.gov/articles/PMC11486521/
Case of a 34-year-old woman.
"This case highlights the need for increased vigilance and research into vaccine-induced autoimmunity."
7,268
Dr John B.

23 Oct, 18:57

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis following the 4th dose of the COVID-19 vaccine -> https://journals.lww.com/neur/fulltext/2024/09000/anti_n_methyl_d_aspartate_receptor_encephalitis.29.aspx
"... the question should be kept in mind whether subsequent booster doses of COVID-19 vaccines are associated with an increased risk of neuroinflammatory complications."
7,304
Dr John B.

23 Oct, 18:43

Severe adverse reaction to measles vaccine rue to homozygous mutation in the IFNAR2 gene -> https://link.springer.com/article/10.1007/s10875-024-01814-6#Sec5
Case of a 10-month-old female infant.
"Following vaccination, she developed viremia, meningoencephalitis, and multi-organ failure."
8,557
Dr John B.

25 Sep, 20:38

Anti-recoverin antibody-associated post-acute COVID-19 vaccination syndrome after BNT162b2 in HLA-B27-positive spondylarthritis: https://pubmed.ncbi.nlm.nih.gov/39280509/
"Two years after the onset of the adverse effects, recurrent elevated recoverin antibodies were detected. Despite the administration of various treatments, most symptoms persisted for more than three years ..."
17,603
Dr John B.

25 Sep, 20:27

Chronic (!) immune thrombocytopenia purpura (ITP) following COVID-19 vaccination: https://journals.sagepub.com/doi/10.1177/00185787241245914
- "ITP in this case is found to have a consistent causal association to COVID-19 vaccination as per the World Health Organization Causality assessment algorithm and is categorized under vaccine product related reactions."
- "One year follow-up conducted showed that the thrombocytopenia following COVID-19 vaccine may be prolonged."
- "Patient perspective: The sudden onset of this disease deteriorated my normal life very badly. [...]
I was totally upset to know that this condition is a result of COVID-19 vaccination which I received and I am wondering why I am suffering from this condition for so long."
16,480
Dr John B.

25 Sep, 20:13

FDA approves AstraZeneca FluMist flu vaccine for self-administration: https://www.flumist.com/
"The following events have been spontaneously reported during post approval use of FluMist or FluMist Quadrivalent": pericarditis, exacerbation of symptoms of mitochondrial encephalomyopathy, anaphylactic reaction, Guillain-Barré syndrome, Bell’s Palsy, meningitis, eosinophilic meningitis, vaccine-associated encephalitis, syncope, ...
https://www.azpicentral.com/pi.html?product=flumist&country=us&popup=no
24,449
Dr John B.

31 Aug, 05:16

Example of how vaccine injury is misrepresented in medical publications:
https://onlinelibrary.wiley.com/doi/10.1002/emp2.13250
This case concerns a child who developed transient synovitis the day after a triple vaccination (PPSV 23, influenza, and DTaP).
On examination in hospital, the PCR COVID-19 test was positive (presumably false positive). The child had no COVID-19 symptoms.
The title of the case report is "A toddler with transient synovitis and COVID-19 infection", but the title should actually be as follows:
26,911
Dr John B.

29 Aug, 07:06

Anti-MDA5 autoantibodies predict clinical dynamics of dermatomyositis (DM) following SARS-CoV-2 mRNA vaccination:
https://link.springer.com/article/10.1007/s00296-024-05683-5
- "MDA-5 antibodies seem to play a role in the autoantibody signature after mRNA vaccination."
- "MDA-5 autoantibodies could serve as potential indicators to predict severe DM progression following mRNA vaccination."
- ".... further studies are required to uncover the underlying mechanisms of autoimmunity triggered by mRNA vaccination."
15,635
Dr John B.

29 Aug, 06:59

Arginine vasopressin deficiency onset after COVID-19 vaccination with positive anti-rabphilin-3A antibodies:
https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-024-01664-8
- Anti-rabphilin-3A antibodies: a known marker for lymphocytic infundibulo-neurohypophysitis (LINH)
- " ... AVP-D due to vaccines other than the SARS-CoV-2 has been limited only with the older smallpox vaccine, with no recent reports from other vaccines, suggesting a possible specific effect of adjuvants in the SARS-CoV-2 vaccine."
13,921
Dr John B.

29 Aug, 06:51

Transient hyperglycemia in a patient with type 2 diabetes after COVID-19 vaccination: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299958/
- "Several cases of hyperglycemia in patients with preexisting diabetes within the setting of COVID-19 vaccination have been reported."
- "... cases of new-onset diabetes and hyperglycemia have been reported after COVID-19 vaccination."
- "Why patients might experience a loss of glycemic control after COVID-19 vaccination is not known."
- "... studies exploring the relationship between vaccine antigen binding and pancreatic function are needed."
10,679
Dr John B.

25 Aug, 13:29

Systemic capillary leak syndrome (SCLS) after COVID-19 vaccination: https://www.tandfonline.com/doi/full/10.1080/21645515.2024.2372149#d1e215
"When patients have acute fever after vaccination with COVID-19 vaccines and are accompanied by hypotension, vomiting, physical discomfort, and tachycardia, in addition to common adverse reactions such as sepsis, allergic reactions, and infections, clinicians also need to pay attention to SCLS."
"11 patients were recovered and were discharged, while 4 patients died."
16,458
Dr John B.

25 Aug, 12:05

High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome:
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1404800/full
- "Compared with controls, PCVS patients had a significantly greater frequency of autoantibodies against peripheral nervous system structures (9/50(18%) vs 1/35(3%); p=0.04)."
- "The evidence supporting the pathophysiological relevance of serum autoantibodies against nervous system tissues, beyond the encephalitis spectrum, is expanding. This trend is based on the increasing number of studies showing links between autoantibody serostatus and unfavorable clinical outcomes in stroke, dementia, and cancer patients."
10,628
Dr John B.

25 Aug, 11:57

Vaccine-associated rheumatic diseases: https://pubmed.ncbi.nlm.nih.gov/39171515/
"... healthcare providers should be aware of the potential of autoimmune manifestations following vaccination, particularly the COVID-19 mRNA and HBV vaccines ..."
"The disproportionality signal for rheumatic diseases was most pronounced in
- HBV vaccines (ROR, 4.11; IC025, 1.90),
- followed by COVID-19 mRNA (ROR, 2.79; IC025, 1.25),
- anthrax (ROR, 2.52; IC025, 0.76),
- papillomavirus (ROR, 2.16; IC025, 0.95),
- encephalitis (ROR, 2.01; IC025, 0.58),
- typhoid (ROR, 1.91; IC025, 0.44),
- influenza (ROR, 1.49; IC025, 0.46),
- and HAV vaccines (ROR, 1.41; IC025, 0.20)."
9,233
Dr John B.

25 Aug, 11:47

Severe acquired hemophilia A after COVID-19 vaccination (BNT162b2, 2nd dose): https://journals.lww.com/md-journal/fulltext/2024/08020/severe_acquired_hemophilia_a_associated_with.25.aspx
A 56-year-old Korean man.
He died.
"This case further highlights the potential safety concerns related to COVID-19 vaccinations."
6,151
Dr John B.

25 Aug, 11:42

Severe cerebral amyloid angiopathy related inflammation (CAA-ri) after COVID-19 vaccination (Coronavac):
https://www.sciencedirect.com/science/article/pii/S0165572824001255#f0005
"... there is emerging evidence that [the] vaccine is capable of eliciting neuroinflammatory responses resembling those seen in CAA-ri ..."
16,335
Dr John B.

25 Aug, 11:35

Type 1 diabetes mellitus after COVID-19 vaccination: 2 cases -> https://link.springer.com/article/10.1007/s13340-024-00695-9
"Although various autoimmune reactions are possible, the mechanism by which COVID-19 vaccine causes type 1 diabetes is not clear and requires further study."
7,140
Dr John B.

25 Aug, 11:26

Acute abducens nerve palsy after COVID-19 vaccination: https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-024-04681-2
"The mechanism behind the pathogenesis of vaccine-induced abducens nerve palsy remains unclear."
"... neurological complications may occur even in otherwise healthy individuals."
10,053
Dr John B.

30 Jul, 20:11

Atypical hemolytic-uremic syndrome after COVID-19 vaccination -> https://onlinelibrary.wiley.com/doi/10.1002/iid3.1270

- "... it is vital to acknowledge the emerging adverse events associated with these vaccines."
- "We agree on the need for more reports of clinical trials are needed to increase understanding of the clinical characteristics and mechanism of the physiopathology of TMA associated with COVID-19 vaccination."
14,721
Dr John B.

30 Jul, 20:04

Varicella zoster reactivation after COVID-19 vaccination:
https://www.cell.com/heliyon/fulltext/S2405-8440(24)08279-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844024082793%3Fshowall%3Dtrue
"This case highlights the importance of considering varicella zoster reactivation in a patient presenting with encephalitis or pneumonia post SARS-CoV-2 vaccination, especially considering the mortality and morbidity associated with these manifestations, if not promptly treated."
12,342
Dr John B.

30 Jul, 19:49

New study:
Blood distribution of SARS-CoV-2 lipid nanoparticle mRNA vaccine in humans
-> https://www.medrxiv.org/content/10.1101/2024.07.25.24311039v1
- "Taken together, our results suggest vaccine mRNA
lipid nanoparticles recirculate for up to 1 month post-vaccination." (!)
- "... mRNA lipid nanoparticles remain intact and travel from injection sites or lymph nodes into blood stream within 4 hours post-vaccination."
- "The rapid dissemination of mRNA lipid nanoparticles in blood found in our study is consistent with the recent findings on the detection of mRNA in breast milk at 3–45 hours post-vaccination."
-"The proteins and lipids bind to mRNA lipid nanoparticles in either lymph or plasma, forming so called “biomolecular corona", which could influence uptake and immunogenicity of the vaccines."
25,249
Dr John B.

30 Jun, 19:10

[1] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253347
[2] https://sciencedirect.com/science/article/pii/S1357272596001550
[3] https://pubmed.ncbi.nlm.nih.gov/21433063/
[4] https://aacrjournals.org/cancerres/article/73/20/6175/584702/Integrin-v-3-and-Fibronectin-Upregulate-Slug-in
[5] https://www.ahajournals.org/doi/full/10.1161/01.cir.96.6.1809
14,825
Dr John B.

30 Jun, 19:10

(13/n)
Interestingly, the SARS-CoV-2 spike arginylglycylaspartic acid (RGD) motif (i.e. the arginine/glycine/aspartic acid amino acid sequence) is similar to that of VN. The RGD motif enables binding to ingerins. (Note: all coronavirus predecessors lack the RGD motif, i.e. it is a specific feature of SARS-CoV-2. SARS-CoV-2 binds to ACE2 and to αVβ3).
The integrin αVβ3 is highly expressed in the endothelium and the SARS-CoV-2 protein has been shown to be able to bind to it [1]. Binding to this ingerin in the epithelium triggers significant endothelial dysregulation, resulting in loss of barrier integrity.
The αvβ3 integrin is also a vitronectin receptor [2], promotes VN gene expression [3] and mediates platelet/endothelium adhesion [4].
Activated integrin αvβ3 in combination with fibronectin also promotes clot invasion and metastasis [5].
12,858

2025 All Right Reserved

Disclaimer: The content displayed on this website is solely provided by the respective Telegram channels. We hold no ownership or responsibility for the content shared by these channels.