621.explanation
Correct answer-C
Answer is C i.e.,Tetracycline.
ACNE VULGARIS
• It is a self-limited disorder primarily of teenagers and
young adults.
• Increase in sebum production by sebaceous glands after puberty is the permissive factor for the disease expression.
• Clinical hallmark of acne vulgaris: Comedone, which
may be closed (whitehead) or open (blackhead).
• The earliest lesions seen in adolescence are generally
mildly inflamed or noninflammatory comedones on the forehead.
• Most common location for acne is the face, but involvement of the chest and back is common.
*Treatment of Acne
• Minimal to moderate pauci-inflammatory disease
respond adequately to local therapy alone: Topical agents
such as retinoic acid, benzoyl peroxide, or salicylic acid.
• Given the image, it is obvious that the case is not a minimal to moderate case of acne vulgaris. It is more likely moderate to acne vulgaris with inflammatory papules, pustules and comedones.
• Harrisons states: “Patients with moderate to severe acne
with a prominent inflammatory component will benefit from the addition of systemic therapy, such as tetracycline in doses of 250–500 mg BD or doxycycline in doses of 100 mg BD”.
• If patients with severe nodulocystic acne are
unresponsive to the therapies discussed above: Treatment
with the synthetic retinoid isotretinoin is the choice. Its
dose is based on the patient’s weight, and it is given once
daily for 5 months.
• Isotretinoin gives excellent result, but its teratogenic side
effects limits its use in reproductive age group females.
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Correct answer
Answer is C i.e.,Tetracycline.
ACNE VULGARIS
• It is a self-limited disorder primarily of teenagers and
young adults.
• Increase in sebum production by sebaceous glands after puberty is the permissive factor for the disease expression.
• Clinical hallmark of acne vulgaris: Comedone, which
may be closed (whitehead) or open (blackhead).
• The earliest lesions seen in adolescence are generally
mildly inflamed or noninflammatory comedones on the forehead.
• Most common location for acne is the face, but involvement of the chest and back is common.
*Treatment of Acne
• Minimal to moderate pauci-inflammatory disease
respond adequately to local therapy alone: Topical agents
such as retinoic acid, benzoyl peroxide, or salicylic acid.
• Given the image, it is obvious that the case is not a minimal to moderate case of acne vulgaris. It is more likely moderate to acne vulgaris with inflammatory papules, pustules and comedones.
• Harrisons states: “Patients with moderate to severe acne
with a prominent inflammatory component will benefit from the addition of systemic therapy, such as tetracycline in doses of 250–500 mg BD or doxycycline in doses of 100 mg BD”.
• If patients with severe nodulocystic acne are
unresponsive to the therapies discussed above: Treatment
with the synthetic retinoid isotretinoin is the choice. Its
dose is based on the patient’s weight, and it is given once
daily for 5 months.
• Isotretinoin gives excellent result, but its teratogenic side
effects limits its use in reproductive age group females.
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